AS350-B2 with a pilot and three passengers on board, took off while it was near a communication tower. During takeoff, the pilot wanted to bypass the tower and conduct a takeoff facing the wind away from the guy wires. Nevertheless, the main rotor came into contact with a guy wire and the aircraft crashed into the ground. The aircraft was substantially damaged. The pilot and one passenger were seriously injured while the two other passengers were not injured.. CADORS 2014Q0581